Shapiro MD

Supporting Research and Documentation.

Our Triple-action hair care aid shampoo originated in January of 2011 by Dermatologists Steven D. Shapiro M.D. and Michael T. Borenstein M.D. Ph.D. after 5 years of previous work on topical DHT (dihydrotestosterone) blockers. They used their background in Clinical Dermatology and patient experience to explore pathways to improving hair. Dr. Shapiro brought 20 years of clinical experience in hair loss and previous hair transplant procedure knowledge to Shapiro MD., Dr. Borenstein brought an intensive scientific background with his PhD in Pharmacology and years of clinical Dermatological experience. Together they have formulated the Shapiro MD Shampoo with three potent naturally occurring DHT blockers in an innovative sulfate free base to be safe and effective in improving hair. Only the best pharmaceutical grade ingredients have been used making this a high quality but cost effective shampoo.

15

Years of Research

The Doctors

2

U.S. Patents

Patent 1 | Patent 2

Clinical Studies of Ingredients

Source:

US National Library of Medicine

Serenoa Repens: Does It have Any Role in the Management of Androgenetic Alopecia?

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Source:

The Journal of Alternative and Complementary Medicine

A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5AR in the Treatment of Androgentic Alopecia

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Source:

International Journal of Pharmaceutical Sciences and Research

Alopecia: Herbal Remedies

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Source:

The Australasian College of Dermatologists

Treatment of male androgenetic alopecia with topical products containing Serenoa repens extract.

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SOURCE:

National Center for Biotechnology Information

Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5α-Dihydrotestosterone Treated Human Dermal Papilla Cells

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SOURCE:

Science Direct

Human Hair Growth Enhancement In Vitro by Green Tea Epigallocatechin-3-gallate (EGCG)

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SOURCE:

Journal of Cosmetic Dermatology

Hair Loss and Herbs for Treatment

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SOURCE:

Journal of Pharmacology & Clinical Research

Formulation and Evaluation of Herbal Hair Gel for Hair Growth Potential

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Journal of Nutritional & Environmental Medicine

Green tea: Health benefits

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SOURCE:

International Journal of Pharmacy and Pharmaceutical Sciences

GREEN TEA (CAMELLIA SINENSIS, L.) ETHANOLIC EXTRACT AS HAIR TONIC IN NUTRACEUTICAL: PHYSICAL STABILITY, HAIR GROWTH ACTIVITY ON RATS, AND SAFETY TEST

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SOURCE:

US National Library of Medicine National Institutes of Health

Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro

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International Journal of Trichology

Role of Caffeine in the Management of Androgenetic Alopecia

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SOURCE:

Journal of Applied Cosmetology

Use of a Caffeine Shampoo for the Treatment of Male Androgenetic Alopecia

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SOURCE:

Journal of Cosmetology and Trichology

Hair Restoration in Androgenetic Alopecia: Looking Beyond Minoxidil, Finasteride and Hair Transplantation

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SOURCE:

International Journal of Dermatology

Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro

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SHAPIRO MD® PATENTS.

The invention generally relates to compositions and methods for treating hair loss, particularly to compositions for treating hair loss by reducing the effects of 5α-dihydrotestosterone (DHT), and most particularly to compositions for treating hair loss including three natural, active ingredients, caffeine, saw palmetto berry extract/derivative, and epigallocatechin-3-gallate (EGCG).

SAW
PALMETTO

Also known as Serenoa Repens Liposterolic Extract, (SPBE) is well known to act with anti-androgenic effects and has been extensively used for Benign Prostatic Hypertrophy. It is a competitive, non-selective inhibitor of 5-alpha reductase types I and II that binds to the DHT receptor on hair follicles. Male patients treated with oral serenoa repens extract showed a significant increase in hair growth in a two year study. 100 men aged 20 to 40 participated in the study. Oral serenoa repens extract was taken orally. 38% of participants increased their hair. Greater than 52% grew or maintained their hair. No adverse events were reported.

EPIGALLOCATECHIN-3-GALLATE (EGCG)

EGCG has very strong antioxidant properties. It is the main active component in Green Tea leaves. EGCG inhibits 5-alpha reductase & reduces androgen action by repressing the transcription of the androgen receptor gene. It also accelerates keratinocyte differentiation & protection of hair follicles from radiation. In vitro exposure of human hair to topical EGCG demonstrated changes that were consistent with in vivo changes for cell proliferation markers in pathways well known to participate in hair growth.

CAFFEINE
DERIVATIVE

Numerous clinical studies have shown caffeine to be effective at blocking DHT. In a study published in the International Journal of Dermatology, researchers saw in vitro growth inhibition of human hair follicles exposed to testosterone. In the same study, the deleterious effects from testosterone were counteracted by low concentrations of caffeine under the same conditions. Additionally, and most importantly, caffeine stimulated growth in the cultured hairs in the same study and under the same conditions. Caffeine penetrates the skin through hair follicles and stratum corneum within 2 minutes in a shampoo formulation.