PATENTED FOR HAIR LOSS
Contains 3 of the most potent naturally occurring active ingredients that have been shown to be effective in the pathway responsible for male and female hair loss.
SAW PALMETTO BERRY EXTRACT (SPBE)
Also known as serenoa repens liposterolic extract, SPBE is well known to act with anti-androgenic effects and has been extensively used for Benign Prostatic Hypertrophy. It is a competitive, non-selective inhibitor of 5-alpha reductase types I and II that binds to the DHT receptor on hair follicles. Male patients treated with oral serenoa repens extract showed a significant increase in hair growth in a two year study. 100 men aged 20 to 40 participated in the study. Oral serenoa repens extract was taken orally. 38% of participants increased their hair. Greater than 52% grew or maintained their hair. No adverse events were reported.
EGCG belongs to the family of catechins. It contains 3 phenol rings & has very strong antioxidant properties. It is the main active component in Green Tea leaves. EGCG inhibits 5-alpha reductase & reduces androgen action by repressing the transcription of the androgen receptor gene. It also accelerates keratinocyte differentiation & protection of hair follicles from radiation. In vitro exposure of human hair to topical EGCG demonstrated changes that were consistent with in vivo changes for cell proliferation markers in pathways well known to participate in hair growth. EGCG stimulates human hair growth through its proliferative and anti-apoptotic effects on dermal papillae cells of hair follicles and may prolong anagen phase of hair growth cycle. In a rat model of baldness, rats given oral green tea had a 33% hair regrowth rate compared to placebo and saw no hair loss. The control group lost hair.
Caffeine is the most commonly ingested drug in the world and a powerful antioxidant. Numerous clinical studies have shown caffeine to be effective at blocking DHT. In a study published in the International Journal of Dermatology, researchers saw in vitro growth inhibition of human hair follicles exposed to testosterone. In the same study, the deleterious effects from testosterone were counteracted by low concentrations of caffeine under the same conditions. Additionally, and most importantly, caffeine stimulated growth in the cultured hairs in the same study and under the same conditions. Caffeine penetrates the skin through hair follicles and stratum corneum within 2 minutes in a shampoo formulation.
DEVELOPED BY DERMATOLOGISTS
“..one of the reasons why we are so passionate about, it's the success of the shampoo, how we’ve helped patients over time. This is the reason that we recommend it. The reality is our patented formula with the proprietary ingredients, has shown real benefits towards our patients on routine basis over a long period of time."
Michael T. Borenstein, M.D., PH.D.
Co-Creator of Shapiro MD
PROVEN INGREDIENTS & SCIENCE
“One of my patients didn’t have any hair for many, many years and he came up to me and he said “can I use this shampoo? Is this okay for me?” I looked at him and I said, "YES, Apply it on a moist scalp up to 20 minutes and you’ll get the maximum benefit. He said “perfect, I swim every morning so I’ll put on the shampoo, have a cup of coffee and read the newspaper before I jump in the shower." He did that and within a short period of time he started to notice hairs forming onto of his scalp then he realized he needed a haircut – his first haircut in three years. After that haircut he realized he had enough hair to start to coloring his hair again which he hand’t done in years! Once the hair was colored it really appeared even thicker and fuller than it ever did and people thought he had a hair transplant - and it basically came down to our shampoo."
Steven D. Shapiro, M.D.
Co-Creator of Shapiro MD